170 * TISSUE ENGINEERED MITRAL VALVE: MORPHOLOGY AND BIOMECHANICS

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Tissue-engineered mitral valve: morphology and biomechanics †.

OBJECTIVES The present study aimed at developing tissue-engineered mitral valves based on cell-free ovine mitral allografts. METHODS The ovine mitral valves (OMVs) (n = 46) were harvested in the local slaughter house. They were decellularized using detergent solutions and DNase. The effectiveness of decellularization was assessed by histological (haematoxylin-eosin, Movat's pentachrome) and i...

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TexMi: development of tissue-engineered textile-reinforced mitral valve prosthesis.

Mitral valve regurgitation together with aortic stenosis is the most common valvular heart disease in Europe and North America. Mechanical and biological prostheses available for mitral valve replacement have significant limitations such as the need of a long-term anticoagulation therapy and failure by calcifications. Both types are unable to remodel, self-repair, and adapt to the changing hemo...

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Tissue engineered aortic valve

Several prostheses are available to replace degenerative diseased aortic valves with unique advantages and disadvantages. Bioprotheses show excellent hemodynamic behavior and low risk of thromboembolic complications, but are limited by tissue deterioration. Mechanical heart valves have extended durability, but permanent anticoagulation is mandatory. Tissue engineering created a new generation h...

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Accessory mitral valve tissue

Accessory mitral valve tissue is a rare congenital malformation. It can be found isolated or in combination with other cardiac anomalies and is usually detected in early childhood. We describe the case of a 74-year-old asymptomatic patient who was referred to our clinic for the evaluation of a heart murmur.

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Morphology of the Human Mitral Valve

Chordae tendineae from 50 normal mitral valves were studied. Four main types can be distinguished by their mode of insertion. Commissural chordae insert into and define the commissures between the anterior and posterior leaflets. Rough zone chordae insert into the ventricular aspect of the distal rough portion of the anterior and posterior leaflets. Such rough zone chordae typically split into ...

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ژورنال

عنوان ژورنال: Interactive CardioVascular and Thoracic Surgery

سال: 2014

ISSN: 1569-9293,1569-9285

DOI: 10.1093/icvts/ivu276.170