17β-estradiol inhibits PPARα of skeletal muscle
نویسندگان
چکیده
منابع مشابه
Effects of 17β-Estradiol and Androgen on Glucose Metabolism in Skeletal Muscle.
Diabetes develops predominantly in males in experimental models, and extensive evidence suggests that 17β-estradiol (E2) modulates progression of diabetes in humans. We previously developed a severely diabetic transgenic (Tg) mouse model by β-cell-specific overexpression of inducible cAMP early repressor (ICER) and found that male ICER-Tg mice exhibit sustained severe hyperglycemia, but female ...
متن کامل17β-estradiol and Testosterone Protect Mitochondria against Oxidative Stress in Skeletal Muscle Cells
We have previously shown that testosterone (T) and 17β-estradiol (E2) protect C2C12 muscle cells against apoptosis induced by hydrogen peroxide (H2O2). Since we also showed the presence of estrogen and androgen receptors in mitochondria, this work was focused on the effects of both steroids on this organelle, which result in cellular survival. Specifically, we evaluated the actions of T and E2 ...
متن کاملMacromolecular prodrugs. XIII. Hydrosoluble conjugates of 17β-estradiol and estradiol-17β-valerate with polyaspartamide polymer.
Two hydrosoluble conjugates of 17β-estradiol (ED) and estradiol-17β-valerate (EV) with polyaspartamide polymer were prepared and characterized. ED and EV were first chemically modified and bound to poly[α,β-(N-2-hydroxyethyl-DL-aspartamide)]-poly[α,β-(N-2-aminoethyl-DL-aspartamide)] (PAHA), a hydrosoluble polyaspartamide-type copolymer bearing both hydroxyl and amino groups. ED was first conver...
متن کاملEffect of Estradiol-17β on Placental Size
Meishan embryos transferred to recipient females on day 2.5 are larger, contain greater numbers of trophectoderm cells, and secrete greater amounts of estradiol-17β when gestated in a Yorkshire compared with Meishan uterus to day 12. Additionally, placentae of Meishan conceptuses are larger when gestated in a Yorkshire compared with Meishan uterus throughout gestation. Embryonic estradiol-17β s...
متن کاملImmunomodulation by 17β-Estradiol in bivalve hemocytes
In mammals, estrogens have both doseand cell-type specific effects on immune cells and may act as pro-inflammatory and anti-inflammatory stimuli depending on the setting. Evidence has been provided that in the bivalve mollusc Mytilus the natural estrogen 17β-estradiol (E2) can affect neuro-immune functions. In this work the immunomodulatory role of E2 in Mytilus hemocytes, the cells responsible...
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ژورنال
عنوان ژورنال: Animal Cells and Systems
سال: 2013
ISSN: 1976-8354,2151-2485
DOI: 10.1080/19768354.2013.831772