16P Understanding the biologic determinants of ribociclib efficacy in breast cancer
نویسندگان
چکیده
منابع مشابه
the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولRibociclib: a valuable addition to treatment options in breast cancer?
Antihormonal treatment is regarded as the prototype of targeted therapy. As early as 1896, George Thomas Beatson proposed surgical oophorectomy for the treatment of patients with locally advanced, inoperable breast cancer. While the underlying biological mechanisms were not understood in those days, the identification of steroid hormones and eventually the oestrogen receptor (ER) led to the suc...
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Clinical and preclinical data support a significant role for inhibitors of the cyclin-dependent kinases (CDKs) 4 and 6 in the treatment of patients with breast cancer. Recently, based on data showing improvement in progression-free survival, the use of palbociclib (Ibrance; Pfizer, Inc.) in combination with endocrine agents was approved to treat patients with hormone receptor-positive advanced ...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2021
ISSN: 0923-7534
DOI: 10.1016/j.annonc.2021.03.030