168: DESCRIPTORS OF FAILED EXTUBATION IN NORWOOD PATIENTS USING PHYSIOLOGIC DATA STREAMING

Introduction: Objective: To evaluate the utility of high-frequency physiologic data during extubation process and other clinical variables for describing profile failure in neonatal patients with hypoplastic left heart syndrome post-Norwood procedure. Methods: Design: Single-center, retrospective analysis Extubation events were collected from January 2016 until July 2021. was defined as need re-intubation within 48 hours extubation. The included streaming rate, respiratory blood pressure, arterial oxygen saturation, near-infrared spectroscopy (NIRS) cerebral renal saturation. most recent laboratory results before also included. These markers, demographics, characteristics, ventilatory settings compared between successful failed extubations. Results: 311 extubations 134 patients. rate 10%. According to univariate analyses, preceded by higher rates (p=0.029), lower end-tidal CO2 (p=0.009), pH (p=0.043), serum bicarbonate (p=0.030), partial pressure O2 (p=0.022). In first 10 minutes after extubation, characterized (p=0.028) NIRS (p=0.018) saturations. Failed associated persistently values saturation 2 post-extubation (p=0.027). As indicated multivariate analysis, vocal cord anomaly (p=0.022), at (p < 0.001), pre-extubation baseline (p=0.001), steady-state (p=0.017), 0.001) found be significant co-variates failure. Conclusions: Oximetric indices before, immediately after, cords paralysis are parallel circulation. Future studies may potential these dynamic markers complement information detect early guide interventions.