1,6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities

The effect of waterpipe smoking and chronic immobilization stress on serum creatine kinase and alkaline phosphatase activities in female rats

Background: Various studies indicate that there is association between life style and various enzyme  activities. This study was conducted to determine the effects of waterpipe smoking and immobilization on serum creatine kinase and alkaline phosphatase activities in female rats. Methods: In this experimental study  female Wistar rats were divided into control, waterpipe smoking, immobilized...

Commonly Used Distributions

Nanoparticle Self-Assembly Directed by Antagonistic Kinase and Phosphatase Activities

Reversible self-assembly is ubiquitous in Nature. The ability to dynamically control the assembly and disassembly of biomolecular complexes is essential to higher-order biological processes, including the control of intracellular communication, gene expression, and platelet aggregation upon injury. To date, assembly or disassembly of nanoparticles (NPs) has been exploited to improve sensitivity...

Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis

Dynamic changes in protein phosphorylation govern the transitions between different phases of the cell division cycle. A "tug of war" between highly conserved protein kinases and the family of phosphoprotein phosphatases (PPP) establishes the phosphorylation state of proteins, which controls their function. More than three-quarters of all proteins are phosphorylated at one or more sites in huma...

Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities.

The aim of this study was to investigate the effect of commonly used botanicals on UDP-glucuronosyltransferase (UGT) 1A4, UGT1A6, and UGT1A9 activities in human liver microsomes. The extracts screened were black cohosh, cranberry, echinacea, garlic, ginkgo, ginseng, milk thistle, saw palmetto, and valerian in addition to the green tea catechin epigallocatechin gallate (EGCG). Formation of trifl...