1563 Abundant oleic acid identifies resolved epidermis with low T-cell–driven IL-17 signature in psoriasis treated with biologics

Local relapses of psoriasis involve educated T cells with the capacity to survive in skin. Inherited from previous flares, tissue-resident memory are prone produce IL-17 resolved epidermis. Their intake fatty acids through FABP5 receptor is essential for their residence and function, we thus hypothesize that surface composition could affect epidermal cell populations. In patients successfully treated biologics, used skin tape-stripping on both non-lesional sites obtained acid by gas chromatography/mass spectrometry (GC/MS). Skin were stimulated OKT-3 explants same body perform bulk transcriptomic analysis Nanostring Technologies The correlation T-cell subsets was performed healthy assessed GC/MS differed between donors normal-looking patients, but not further Patients whom rich oleic exhibited a lower T-cell–driven signature upon activation explants. This finding restricted epidermis found patients. Overall, our findings link first time functionality underlying microenvironment. Testing modulating effect custom fatty-acids resident hopefully help erasing disease inflammatory diseases decrease burden.