1501 Hydroxychloroquine restores burn damage through the Wnt/β-catenin pathway

Background: Repairing the burn-injury induced cell death and improving wound healing are critical issues. Objectives: This study was focused on assessment of hydroxychloroquine (HCQ)- recovered burn injury in vivo vitro models. Materials & Methods: In this study, we constructed animal models second-degree burns, showed that heating at 55 Celsius degree for 5 min caused skin cells to switch from apoptosis stage necrosis stage. We investigated expression Wnt/ β-catenin pathway markers autophagy related proteins model. Results: HCQ could significantly decrease burn-induced cycle. Here, demonstrated protected Bip p62 protein prevented LC3B rising continuously. allowed cellular migration accelerate burned HaCaT an dorsal The addition ICG001 inhibitor Wnt/β-catenin reduced HCQ’s ability promote healing. reduce by injury. restored burned-dorsal repairs damage through pathway. Conclusions: Our results first reveal new applications HCQ. protect cells. marker β-catenin, essential activating signaling, repair pathway, while triggering vivo.