15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.
PURPOSE We have investigated the expression and regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in gastric cancer. EXPERIMENTAL DESIGN Clinical gastric adenocarcinoma samples were analyzed by immunohistochemistry and quantitative real-time PCR for protein and mRNA expression of 15-PGDH and for methylation status of 15-PGDH promoter. The effects of interleukin-1beta (IL-1beta) an...
متن کاملPrognostic Implication of 15-Hydroxyprostaglandin Dehydrogenase Down-Regulation in Patients with Colorectal Cancer
PURPOSE Prostaglandin (PG) E2 is known to be closely related to cancer progression and is inactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). 15-PGDH is shown to have tumor suppressor activity and to be down-regulated in various cancers, including colorectal cancer (CRC). Therefore, we evaluated the expression of 15-PGDH and its prognostic effect in patients with CRC. METHODS 15-PGDH...
متن کاملGenetic Variation in 15-Hydroxyprostaglandin Dehydrogenase and Colon Cancer Susceptibility
BACKGROUND 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE2) and other prostanoids. Recent studies have established the 15-PGDH gene as a colon cancer suppressor. METHODS We evaluated 15-PDGH as a colon cancer susceptibility locus in a three-stage design. We first genotyped 102 single...
متن کاملRepression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.
Prostaglandin E(2) (PGE(2)) promotes cancer progression by modulating proliferation, apoptosis, angiogenesis, and the immune response. Enzymatic degradation of PGE(2) involves the NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Recent reports have shown a marked diminution of 15-PGDH expression in colorectal carcinomas (CRC). We report here that treatment of CRC cells with his...
متن کاملFocusing downstream in lung cancer prevention: 15-hydroxyprostaglandin dehydrogenase.
Deregulated inflammatory mediators and growth factors seem to act in concert with mutational events in driving malignant transformation and progression, thus contributing to the complex pulmonary environment in the lung at risk for cancer. Pulmonary diseases that are associated with the greatest risk for malignancy are characterized by abundant and deregulated inflammation (1). Profound abnorma...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m411221200