14 Years of Polish Experience in Non-Invasive Prenatal Blood Group Diagnosis

14 Years of Polish Experience in Non-Invasive Prenatal Blood Group Diagnosis.

BACKGROUND Blood cell antigens may cause maternal alloimmunization leading to fetal/newborn disorders. Non-invasive prenatal diagnostics (NIPD) of the blood group permits the determination of feto-maternal incompatibility. AIM To evaluate 14 years of blood group NIPD at the Institute of Hematology and Transfusion Medicine (IHTM) in Warsaw. METHODS Plasma DNA from 536 RhD-negative, 24 Rhc-ne...

Invasive or non-invasive prenatal genetic diagnosis?

About 40 years ago, invasive prenatal diagnosis techniques were introduced in obstetrics. Initially, amniocentesis was performed followed by placentacentesis, fetoscopy, fetal blood sampling (FBS), and chorionic villus sampling (CVS). These procedures, while invading the uterine environment, have made it possible to proceed with the retrieval of biological tissue of fetal origin for analysis an...

Non-invasive prenatal diagnosis of Down's syndrome.

Down syndrome (trisomy 21), which has an incidence of 1 in 800 live births, is considered to be the most frequent etiology of mental retardation and it is the predominant reason for women seeking prenatal diagnosis [Driscoll & Gross, 2009]. Trisomy 21 is used as a benchmark because it is the most common aneuploidy compatible with life and is associated with mental retardation and serious congen...

Non Invasive Prenatal Diagnosis of Down Syndrome

What potent blood: non-invasive prenatal genetic diagnosis and the transformation of modern prenatal care.

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