13C NMR relaxation and conformational flexibility of the deoxyribose ring
نویسندگان
چکیده
منابع مشابه
Conformational Flexibility in Nucleic Acids Investigated by NMR Relaxation
Vol. k, No. 3/4 All of the different steps in these processes involving nucleic acids, including control steps, require recognition of unique sites on the nucleic acids, which may be short-lived. The packaging of polynuc1eotides into compact forms in chromatin, ribosomes, and viruses involves folding of the nucleic acids. These and other observations indicate that the deformation of polynucieot...
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Using (13)C spin relaxation NMR in combination with molecular dynamic (MD) simulations, we characterized internal motions within double-stranded DNA on the pico- to nano-second time scale. We found that the C-H vectors in all cytosine ribose moieties within the Dickerson-Drew dodecamer (5'-CGCGAATTCGCG-3') are subject to high amplitude motions, while the other nucleotides are essentially rigid....
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We have performed molecular dynamics (MD) simulations of a melt of 1,4-polybutadiene (PBD, 1622 Da) over the temperature range 400-273 K. 13C NMR spin-lattice relaxation times (T1) and nuclear Overhauser enhancement (NOE) values have been measured from 357 to 272 K for 12 different resonances. The T1 and NOE values obtained from simulation C-H vector P2(t) orientational autocorrelation function...
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Rotational diffusion properties have been derived for the DNA dodecamer d(CGCGAATTCGCG)(2) from (13)C R(1rho) and R(1) measurements on the C(1'), C(3'), and C(4') carbons in samples uniformly enriched in (13)C. The narrow range of C-H bond vector orientations relative to the DNA axis make the analysis particularly sensitive to small structural deviations. As a result, the R(1rho)/R(1) ratios ar...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1982
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/10.19.6067