1315 An Integrated model of alopecia areata biomarkers highlights both Th1/Th2 upregulation, with stronger correlations between Th2 activation and disease severity
نویسندگان
چکیده
منابع مشابه
The influence of osteopontin on the pathogenesis of alopecia areata and its association with disease severity
Background: Alopecia Areata (AA) is an autoimmune disease affecting hair follicles. Although many details are well specified in the pathogenesis of the disease, there exist certain aspects which require more investigations. Given the fact that the increase in Th-1 immunity is the essential part of the pathogenesis, the incrimination of osteopontin, as a Th-1 cytokine, is considered appropriate ...
متن کاملFactors Associated with Severity of Alopecia Areata
BACKGROUND Alopecia areata is the most common cause of localized, nonscarring alopecia. Unfortunately, there are few data regarding clinical features and epidemiology of alopecia areata in Korean patients, and its clinical course and treatment response rates are unpredictable. OBJECTIVE This study strived to investigate the differences in clinical profiles according to disease severity and to...
متن کاملPersonality characteristics and severity of depression in alopecia areata patients
The relationship between psychological factors and alopecia areata is already a controversial issue. Previous researches have mainly focussed on the impact of stressors and occasionally the underlying psychiatric disorders. The relationship of personality with this disease has not been investigated. A group of alopecia areata patients ( n=31) was compared with a control group ( n=31) of age mat...
متن کاملCorrelation between the severity of alopecia areata and its risk factors
Background: Alopecia Areata (AA) is a recurrent non-scarring type of hair loss that can affect any hair-bearing area. Prognosis of AA is unpredictable and most patients experience more than one episode of hair loss. The purpose of this study was to investigate the relationship between the severity of AA with respect to age of onset, nail involvement, family history, number of recurrences and du...
متن کاملAlopecia areata in patients with inflammatory bowel disease: an overview.
Alopecia areata (AA) is one of the most common causes of non-scarring hair loss, which is associated with the premature induction of hair follicle regression. The pathogenesis of AA is unknown, although it is believed that a complicated autoimmune mechanism with Th1 lymphocytes and proinfammatory cytokines, such as IFN-γ, TNF-α, IL-1 and IL-2, may be involved. AA may occur as a single disease e...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.1332