(129) A Neurological Excitation/Inhibition “Faucet Model” for Orgasm and Pain

Abstract Introduction A prevalent concept of neuronal inhibition in sexual response is that it opposes the effects excitation, e.g., classical arm balance which excitation and are on opposite arms balance; when one up, other down (Perelman: Curr Sex Health Rep 2018;10:38). However, there extensive evidence can increase jointly concurrently with excitation. Objective To review increasing various contexts including orgasm. Methods Review neurological propose a novel model acting to enable intense Results The intensity an thereby actually enabling increase, as most basic functions nervous system, i.e., spinal reflexes, graceful, non-spastic movement precision, movement. Sensorially, pain activates endogenous pain-inhibiting system. In response, vaginal self-stimulation increased from pressure pleasure orgasm, also increased. spinothalamic tract, transmits pain, genital stimulation leading brain, major components activated by sites inhibitory interactions between afferent activity perception. When surpasses concurrent inhibition, perceived aversive or painful (Komisaruk & delCerro: Med Rev 2022;10:481). We this view both hot (excitatory) cold (inhibitory) water flowing faucet. This differs incorporates variations independently each well jointly, rather than just reciprocally. Thus, low versus high flow rate would represent mild whereas intense, but non-painful, comfortable perhaps exceeding at Weak, “anhedonic” premature ejaculation represented “faucet model” very rate; anorgasmia and/or “HSDD” consistently surpassing any rate, high, depending dynamic qualities anorgasmia, not “getting going”, close, there”, regard latter case titrated combination excitatory (hot) (cold) pharmaceuticals might more delayed Conclusions Our proposed mediating based evidence, we believe account for variety healthy pathological responses, provide rational basis therapeutic application. Disclosure Any authors act consultant, employee shareholder industry for: Adamo Bioscience (first author); many others (last author).