1,2,3-Triazole–quinazolin-4(3H)-one conjugates: evolution of ergosterol inhibitor as anticandidal agent
نویسندگان
چکیده
منابع مشابه
2-Morpholinoethylisocyanide as a coupling agent for hapten-protein conjugates
Conjugation of haptens to proteins and enzymes is essential for the production of antibodies and development of ELISAs for these low molecular weight compounds. In this study, protein conjugates of several carboxylic haptens were prepared using the peptide synthesis reagent, 2-morpholinoethylisocyanide. The haptens included derivatives of benzimidazole and pyridoxine. The main advantage of this...
متن کاملCassia Essential Oil: Effective Anticandidal and Possible Therapeutic Agent
The antimicrobial property of volatile aromatic oils from medicinal as well as other edible plants has been recognized since antiquity. Candida species are an important cause of opportunistic infections in the oral cavity of immunocompromised patients and vaginal candidiasis. The antifungal activity of the essential oil of Cinnamomum cassia (cassia oil) was investigated against 75 clinical isol...
متن کاملSynthesis of some oxadiazole derivatives as new anticandidal agents.
In this study, 5-[(pyrimidin-2-ylthio)methyl]-1,3,4-oxadiazole-2(3H)-thione (3) was synthesized via the ring closure reaction of 2-(pyrimidin-2-ylthio)acetohydrazide (2) with carbon disulphide. New oxadiazole derivatives 4a-f were obtained by the nucleophilic substitution reaction of compound 3 with various phenacyl bromides. The chemical structures of the compounds were elucidated by IR, 1H-NM...
متن کاملUse of a prenylation inhibitor as a novel antiviral agent.
No specific therapy exists for hepatitis delta virus (HDV), which can cause severe liver disease. Molecular genetic studies have implicated the prenylation site of large delta antigen as a critical determinant of HDV particle assembly. We have established a cell culture model which produces HDV-like particles, and we show that delta antigen prenylation can be pharmacologically inhibited by the ...
متن کاملevaluation of sd-208, a tgf-β-ri kinase inhibitor, as an anticancer agent in retinoblastoma
retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. the objective of this study was to investigate the effects of sd-208, tgf-β-ri kinase inhibitor, on the expression of some mirnas including a mir-17/92 cluster in retinoblastoma cells. prior to initiate this work, the cell proliferation was studied by me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RSC Advances
سال: 2018
ISSN: 2046-2069
DOI: 10.1039/c8ra08426b