123 ATF3 distinguishes between innate and adaptive immunity

To answer whether innate immunity causes autoinflammation or initiate adaptive response, we focused on ATF3, which functions as a regulator in early signaling. Therefore, studied the impact of ATF3 and response vivo. In previous works observed opposing effects either immune responses. We further evaluated relevance for T cell-mediated context contact hypersensitivity. Atf3ko wt mice were sensitized with TNCB challenged. After challenge, cell-associated cytokines Il2 Il4 induced almost at background mice. Tissue from showed reduced levels Ifn Cxcl10. Il6 was increased Atf3ko, while mRNA IL-1 cytokine family members similar Coinciding, stronger infiltrate neutrophils. analyzed draining lymph nodes via FACS revealed delayed migration DCs ATF3ko Further, Atf3-deficient an irregular shape dysregulated actin formation contrast to DCs. determine effect responses, CD4+ cells isolated nodes. Indeed, but not Atf3-/- mice, also significantly Ifng compared controls. Investigating role antigen presentation, co-cultures OTII-CD4+ T-helper cells. As constant, lower Ifn, co-culture summary, our data suggest that suppression does stimulate both immunity, promotes state enhanced neutrophil recruitment DC dysfunction suppressed cell activation.