1226 Arctigenin (ATG)-enriched burdock seed oil (ABSO): A new ATG-enriched botanical extract with skin brightening properties

The Arctium lappa L. plant, commonly known as burdock, has been used therapeutically for hundreds of years. Arctigenin (ATG) is an active ingredient in albeit at low quantities or mostly the form acrtiin (arctigenin-4-glucoside). ATG touted its anti-inflammatory properties many cell types and disease states; however, role skin melanin production not extensively studied. Our aims this study were to develop a burdock seed extract enriched that amenable quasi-drug development, determine vitro brightening activity, evaluate safety efficacy clinically human subjects. Arctiin content measured by high-performance liquid chromatography (HPLC). In studies utilized EpiDermTM tissues irritation test, MelanoDermTM reduction capacity. A 45 subject clinical was performed adult subjects ranging age from 30 60 years old (mean = 41.9 ± 6.7) test potential 1% ABSO lotion. We demonstrate HPLC natural ex-tract contains ∼5-times more arctigenin than BSO. Furthermore, inhibits better BSO retains same melanin-reducing capacity synthetic MelanoDerm™ 3D cultures. also adheres criteria according Japanese Standards Quasi-Drug Ingredients determined infrared absorption spec-trum method, unsaponifiable matter, heavy metal arsenic content, acid, saponification, iodine value methods. Clinical assessment lotion shows it well-tolerated demonstrates improved brightness tone evenness. arctigenin-enriched reduces improves brightness.