12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis

Arthritis Inflammation and Tissue Damage in 12/15-Lipoxygenase Counteracts

Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators.

PGs and leukotrienes (LTs) mediate cardinal signs of inflammation; hence, their enzymes are targets of current anti-inflammatory therapies. Products of arachidonate 15-lipoxygenases (LO) types I and II display both beneficial roles, such as lipoxins (LXs) that stereoselectively signal counterregulation, as well as potential deleterious actions (i.e., nonspecific phospholipid degradation). In th...

Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C.

The effects of three anti-inflammatory drugs, which interfere with arachidonic acid transformation by three different enzymes, have been compared by using a simple model of tissue damage and foreign body rejection. In groups of control rats, subcutaneously implanted polyester sponges were rejected after a mean of 12 days. Indomethacin, which selectively inhibits prostaglandin synthesis, did not...

Low-grade chronic inflammation and vascular damage in patients with rheumatoid arthritis: don't forget "metabolic inflammation".

Macrophages and fibroblasts during inflammation, tissue damage and organ injury.

Inflammation is a highly complex cellular surveillance system that is essential for anti-microbial defense and wound healing. The inflammatory process relies on multifaceted coordination among various body systems. Many host cells including leukocytes, fibroblasts, endothelial cells and epithelial cells are involved in the inflammatory process. Cellular receptors, such as Toll-Like-Receptors (T...