منابع مشابه
+ 12 or trisomy 12
Phenotype/cell stem origin virgin CD5+ recirculating B-cell; the classical CLL phenotype is CD5+, CD23+, CD22-, CD79a-, FMC7-, sIg weak; trisomy 12 is more often observed in CLL with morphologically and immunologically atypical cells, displaying CD5 negativity or FMC7 positivity and strong surface immunoglobulin staining; trisomy 12 is present in proliferating cells and seems to be associated w...
متن کاملNOTCH1 mutations in CLL associated with trisomy 12.
Two recent studies reported whole-genome sequencing of chronic lymphocytic leukemia (CLL) samples and found repeated mutations in the XPO1 and NOTCH1 genes. XPO1 was found mutated in 2.4% of cases, while NOTCH1 was found mutated in 12.2% or 15.1% of CLL samples. Here we report the results of sequencing of XPO1 and NOTCH1 in 186 CLL cases. Our results confirmed frequency of XPO1 mutations. Howev...
متن کاملTrisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study.
Interphase cytogenetics by means of in situ hybridization with the chromosome 12-specific biotinylated alpha satellite DNA probe pSP 12-1 was used for the study of trisomy 12, the most common chromosomal abnormality in chronic lymphocytic leukemia. In situ hybridization was performed on methanol/acetic acid fixed cells of conventional cytogenetic preparations from eight patients and on morpholo...
متن کاملObinutuzumab-induced coagulopathy in chronic lymphocytic leukaemia with trisomy 12
Obinutuzumab, an afucosylated, type 2 anti-CD20 antibody, showed superior results to rituximab in a head-to-head comparison in combination with chlorambucil in the first-line treatment of chronic lymphocytic leukaemia (CLL) patients with comorbidities in the CLL11 trial (NCT01010061). Enhanced activity of obinutuzumab in this setting may reflect better binding to Fc receptors as well as the dir...
متن کاملAbnormal neural fold development in trisomy 12 and trisomy 14 mouse embryos. I. Scanning electron microscopy.
The early development of the exencephalic malformation in trisomy 12 (Tsl2) and trisomy 14 (Tsl4) mouse embryos was examined by means of scanning electron microscopy and compared with cranial neural tube formation in euploid litter-mates. Embryos from normal laboratory mice were used as additional controls. The euploid control embryos of the trisomy-inducing breeding system showed a slight dela...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37627