110 HPV-Positive Oropharyngeal Cancer: A Review of De-Escalation Strategies Used to Improve Outcomes for This Patient Cohort

Abstract Aim Human Papillomavirus (HPV) positive oropharyngeal cancer (OPC) has been shown to provide improved survival compared HPV negative patients with similar disease. This led a new staging criteria for these and attempts de-escalate treatment this group, maintain high reduce associated side effects. review aims assess current research into techniques compare results of studies. Method Pubmed online database was used gather studies containing primary dated from within the last 10 years detailing study design, striation higher lower risk groups, outcome de-escalation groups. Results Published vary in their definition ‘low risk’ however minimal smoking history, smaller tumour size increased DNA expression are all identified as good prognostic indicators could be have identify suitable candidates deintensification. The combination radiotherapy chemotherapy often success however, no consensus reached regarding dosing these. Transoral robotic surgery may also conjunction chemoradiotherapy, large ongoing yet publish final results. Conclusions is an evolving area oncology increasing evidence base improving prognosis minimising effects group patients, more necessary gain on gold standard patients.