1055 MALMÖ POTS SYMPTOM SCORE: ASSESSING SYMPTOM BURDEN IN POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME

Abstract Background Postural orthostatic tachycardia syndrome (POTS) is a common cardiovascular autonomic disorder characterized by excessive heart rate increase on standing and symptoms of intolerance, posing significant limitations functional capacity. No objective tool exists to classify symptom burden in POTS. Methods We conducted case-control study 62 POTS patients 50 healthy controls compare between groups using the newly developed, self-rating, 12-item, Malmö Score (MAPS; 0-10 per item, total range 0-120) based patients’ own perception through visual analogue scale assessment. have also explored correlations severity assessed MAPS, basic clinical parameters postural haemodynamic changes. Results showed significantly higher MAPS score (78±20 vs. 14±12, p<0.001), baseline systolic blood pressure (BP), diastolic BP (HR)(p<0.001) compared with controls. The most prominent were palpitations, fatigue, concentration difficulties. Haemodynamic correlated palpitations after adjustment for age sex (lower BP, HR) (p<0.001 all). Orthostatic HR was associated difficulties score. optimal cut-point value differentiate ≥42 (sensitivity, 97%; specificity, 98%). Conclusions Symptom severity, as score, 5-fold individuals. new can be useful semi-quantitative system assess burden, monitor disease progression evaluate pre-test likelihood disease.