104 Cbf-β is required for the development, differentiation, and function of murine mucosal-associated invariant T cells

Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved subset of cells, which mediate functions that link innate and acquired immunity in a broad spectrum diseases, including infectious, autoimmune skin diseases. Although transcription factors such as PLZF, SATB1, miR-181a/b-1, miR-155, Drosha, SAP have been shown to regulate MAIT cell development differentiation, significant gap our knowledge regulation remains. Using previously published scRNA-seq dataset, we observed increase Cbf-β expression stage 3 led us investigate the effect on cells. We found deficiency murine impaired interrupted MAIT1 MAIT17 differentiation. Additionally, inducible deletion inhibited activation cytotoxicity peripheral Our work elucidates mechanism identifies novel target, Cbf-β, for modulation applications cell-based immunotherapies.