1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione
نویسندگان
چکیده
A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields no further purification. Therefore, the proposed method, an overall yield 60%, offers a facile pathway to N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute privileged class heterocyclic scaffolds pharmacological interest.
منابع مشابه
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ژورنال
عنوان ژورنال: Molbank
سال: 2021
ISSN: ['1422-8599']
DOI: https://doi.org/10.3390/m1228