α1-Adrenoceptor subtypes of rat heart.
نویسندگان
چکیده
منابع مشابه
Functional role of α1-adrenoceptor subtypes in murine ophthalmic arteries.
PURPOSE To identify the α(1)-adrenoceptor (α(1)-AR) subtypes mediating vascular adrenergic responses in murine ophthalmic arteries. METHODS Expression of mRNA was quantified for individual α(1)-AR subtypes in murine ophthalmic arteries using real-time PCR. To assess the functional relevance of α(1)-ARs for mediating vascular responses, ophthalmic arteries from mice deficient in one of the thr...
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Some large vessels have a mixed functional population of postjunctional α1- and α 2-adrenoceptors. The purpose of the work presented here was to investigate the population of postjunctional α -adrenoceptors in the rat isolated common carotid artelY Male Wi star rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings...
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We investigated the a,-adrenoceptor subtypes of rabbit saphenous vein which has a mixed functional population of α1 and α2 -adrenoceptors. Lateral saphenous veins were obtained from male rabbits weighing 3.20-4 kg, which were killed by overdose with pentobarbitone sodium (i.v. injection). They were easily dissected out and placed in cold, oxygenated modified Krebs-Henselite solution (Krebs)...
متن کاملTheoretical proton affinities of α1 adrenoceptor ligands
A systematic study has been performed of the proton affinity of a large family of agonists and antagonists of the α1-adrenoceptor at the B3LYP/6-31G* level of theory. After a conformational search, all the N atoms were considered as protonation sites and protonation energy values were determined. The inclusion of solvation by means of the Onsager model yielded stabilization in the proton affini...
متن کاملcontractions due to α-adrenoceptor agonists are mediated by α1-adrenoceptors in rat carotid artery
some large vessels have a mixed functional population of postjunctional α1- and α 2-adrenoceptors. the purpose of the work presented here was to investigate the population of postjunctional α -adrenoceptors in the rat isolated common carotid artely male wi star rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. rings of ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)51901-1