α1-ADRENOCEPTOR ACTIVATION CAN INCREASE HEART RATE DIRECTLY OR DECREASE IT INDIRECTLY THROUGH PARASYMPATHETIC ACTIVATION
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Nitric oxide donors can increase heart rate independent of autonomic activation.
Administration of nitric oxide (NO) donors in vivo is accompanied by a baroreflex-mediated increase in heart rate (HR). In vitro, however, NO donors can increase HR directly by stimulating a pathway that involves NO, cGMP, and the hyperpolarization-activated current (I(f)). The aim of this study was to assess the functional significance of this pathway in vivo by testing whether NO donors can i...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1982
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1982.tb09301.x