1, 1-Bis (2-chloroethyl) hydrazine and its Antitumor Activity
نویسندگان
چکیده
منابع مشابه
(E,E)-1,2-Bis[1-(2-bromophenyl)ethylidene]hydrazine
In the title compound, C(16)H(14)Br(2)N(2), the complete molecule is generated by a crystallographic twofold axis. The dihedral angle between the two benzene rings is 35.28 (8)° and that between the best planes of two ethyl-idinehydrazine N-N=C-Me units is 87.67 (11)°. Each of these N/N/C/C planes makes a dihedral angle of 63.81 (10)° with the adjacent benzene ring. In the crystal, the mol-ecul...
متن کاملN,N'-bis[1-(pyrazin-2-yl)ethylidene]hydrazine.
Molecules of the title compound, C12H12N6, contain both a diimine linkage and an N-N bond, and assume a planar structure. The compound lies about an inversion centre and there are three intramolecular C-H...N hydrogen bonds.
متن کاملIn Vivo Antiviral Activity of 1,3-bis(2-chloroethyl)-1-nitrosourea.
A prolongation in the lives of Swiss mice inoculated intracerebrally with lymphocytic choriomeningitis virus (LCM) was observed after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). A variety of treatment schedules, including therapy once or twice daily up to 17 days and single treatments at various times after virus inoculation, were employed. Virus titers ranging to greater than 1...
متن کاملThe uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the murine glioma.
The antitumor activity of 1-(2-cMoroethyl)-3-cyclohexyl-1nitrosourea (CCNU) against the murine ependymoblastoma, glioma 26, and glioma 261 was compared with the uptake and distribution of the †̃ 4C-labeled drug in the murine ependymoblastoma. With a modified Wilcoxon rank-sum test, it was found that CCNU increased life-span in tumor animals from 2to 4-fold, depending on the dose used and the p...
متن کاملInterstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas.
Bifunctional alkylating agents are known to cross-link DNA by simultaneously alkylating two guanine residues located on opposite strands. Despite this apparent requirement for bifunctionality, 1-(2-chloroethyl)-1-nitrosoureas bearing a single alkylating function were found to cross-link DNA in vitro. Cross-linking was demonstrated by showing inhibition of alkali-induced strand separation. Exten...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1959
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.7.391