099 Identification of T cell receptor chains responsible for alopecia areata pathogenesis via bulk and single cell TCR sequencing
نویسندگان
چکیده
منابع مشابه
Immunohistochemical analysis of T-cell subsets in the inflammatory infiltrates of alopecia areata and its comparison with androgenetic alopecia
Background: Androgenic hair loss (AGA) and alopecia areata (AA) are common conditions which sometimes are histologically difficult to differentiate. This study was conducted to detect differentiating features of these two disorders with IHC analysis of T-cell subsets in the inflammatory infiltrates of alopecia areata and androgenetic alopecia. Methods: This cr...
متن کاملThe influence of osteopontin on the pathogenesis of alopecia areata and its association with disease severity
Background: Alopecia Areata (AA) is an autoimmune disease affecting hair follicles. Although many details are well specified in the pathogenesis of the disease, there exist certain aspects which require more investigations. Given the fact that the increase in Th-1 immunity is the essential part of the pathogenesis, the incrimination of osteopontin, as a Th-1 cytokine, is considered appropriate ...
متن کاملDiagnostic role of tests for T cell receptor (TCR) genes.
Rapid advances in molecular biological techniques have made it possible to study disease pathogenesis at a genomic level. T cell receptor (TCR) gene rearrangement is an important event in T cell ontogeny that enables T cells to recognise antigens specifically, and any dysregulation in this complex yet highly regulated process may result in disease. Using techniques such as Southern blot hybridi...
متن کاملAlopecia areata update: part I. Clinical picture, histopathology, and pathogenesis.
UNLABELLED Alopecia areata (AA) is an autoimmune disease that presents as nonscarring hair loss, although the exact pathogenesis of the disease remains to be clarified. Disease prevalence rates from 0.1% to 0.2% have been estimated for the United States. AA can affect any hair-bearing area. It often presents as well demarcated patches of nonscarring alopecia on skin of overtly normal appearance...
متن کاملAlopecia areata: Part 1: pathogenesis, diagnosis, and prognosis.
OBJECTIVE To provide family physicians with a background understanding of the epidemiology, pathogenesis, histology, and clinical approach to the diagnosis of alopecia areata (AA). SOURCES OF INFORMATION PubMed was searched for relevant articles regarding the pathogenesis, diagnosis, and prognosis of AA. MAIN MESSAGE Alopecia areata is a form of autoimmune hair loss with a lifetime prevalen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.103