099 E-Cadherin is dispensable for epidermal localization of Langerhans cells
نویسندگان
چکیده
منابع مشابه
Epidermal ADAM17 is dispensable for Notch activation
Animals The generation of Adam17 flox/flox Krt14-Cre, Egfr flox/flox Krt14-Cre and Adam10 flox/flox Krt14-Cre mice has been described previously (Franzke et al., 2012; Weber et al., 2011). All mice were of mixed genetic background (129Sv, C57BL/6), and all comparisons were between littermates. The mice were maintained in the Biomedical Research Center of the University Medical Center in Freibur...
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Human skin contains the following two distinct DC subsets: (i) Langerhans cells (LCs), expressing Langerin but not DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), are predominantly localized in the epidermis; and (ii) dermal DCs, expressing DC-SIGN but not Langerin, are observed mainly in the dermis. It is not known whether localization in the epidermis provides cu...
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Immunocytochemical techniques using antibodies to the specific T6 and Ia (Major Histocompability Complex, class 11, human HLA-Dr) antigens were used to determine the densities of epidermal Langerhans cells (LC) in psoriasis patients treated with the aromatic retinoid RO 10-9359. Fourteen patients were treated with the aromatic retinoid and were skin biopsied before, during and after therapy. Tw...
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The effects of topical and systemic administration of various glucocorticoids on the density of epidermal Langerhans cells (LC) were studied in guinea pigs. Glucocorticoids, such as betamethasone dipropionate and valerate, caused a marked decrease in LC demonstrable by staining for cell membrane ATPase activity and Ia antigens. By electronmicroscopy, LC also showed morphologic alterations. The ...
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Langerhans' cells were studied in the epidermis of two patients with active Behçet's disease and compared with those in two normal controls. Ultrastructural morphology and the percentage of Langerhans' cells found were similar in patients' (1.88%) and the control epidermis (1.79%). The density of Langerhans' cells in adjacent sites of the same epidermis was not homogeneous, being in the range o...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.07.409