083 CXCR4-expressing skin-resident NKT cells develop allergic inflammation in atopic dermatitis

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Atopic dermatitis: a paradigmatic allergic skin disease.

environment or a more susceptible population? Thorax 1994; 49: 171–174. 9. Holgate ST. The epidemic of allergy and asthma. Nature 1999; 402 (6760 Suppl): B2–B4. 10. Holt PG, Macaubas C, Stumbles PA, Sly PD. The role of allergy in the development of asthma [review]. Nature 1999; 402: B12–B17. 11. Strachan DP, Harkins LS, Johnson ID, Anderson HR. Childhood antecedents of allergic sensitization in...

متن کامل

Atopic dermatitis: allergic dermatitis or neuroimmune dermatitis?*

Advances in knowledge of neurocellulars relations have provided new directions in the understanding and treatment of numerous conditions, including atopic dermatitis. It is known that emotional, physical, chemical or biological stimuli can generate more accentuated responses in atopic patients than in non-atopic individuals; however, the complex network of control covered by these influences, e...

متن کامل

The underlying mechanisms of skin inflammation in atopic dermatitis

The underlying mechanisms of skin inflammation in atopic dermatitis (AD) are not completely understood but inflammatory cell activation and dysregulated cytokine production appear to play a critical role in pathogenesis of AD. Inducible nitric oxide synthase (iNOS) is expressed by dermal endothelial cells and perivascular inflammatory cells in the atopic skin lesion, suggesting the involement o...

متن کامل

Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation

Airborne exposure to microbial cell wall lipids such as lipopolysaccharide triggers innate immune responses that regulate susceptibility to allergic airway inflammation. α-Glycosylceramides represent another widespread class of microbial lipids that directly stimulate innate-like, IL-4- and IL-13-producing, CD1d-restricted NKT cells. In this study, we demonstrate that NKT cells constitutively a...

متن کامل

Skin barrier in atopic dermatitis.

The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in particular atopic dermatitis (AD). This review ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2018

ISSN: 0022-202X

DOI: 10.1016/j.jid.2018.03.087