073 D-dopachrome tautomerase overexpression accelerates photocarcinogenesis in mice

Ultraviolet irradiation (UV) exposure constitutes the most relevant environmental hazard to human skin. UV-mediated cutaneous inflammation and direct DNA damage lead promotion of skin carcinogenesis. D-dopachrome tautomerase (D-DT), a functional homolog macrophage migration inhibitory factor (MIF), has similarities MIF. However, its role, unlike role MIF in photocarcinogenesis, is unknown. We therefore explored D-DT photocarcinogenesis by developing transgenic (D-DT Tg) mice provided research model for future studies targeting D-DT. Chronic UVB accelerated tumor development Tg compared with wild-type (WT) mice, higher incidence tumors observed than WT mice. In irradiated mouse keratinocytes, p53, PUMA, Bax expression were lower that These results indicate overexpression confers prevention against UVB-induced apoptosis keratinocytes. Taken together, these findings support isas functionally important cytokine potential therapeutic target carcinogenesisphotocarcinogenesis.