060 The effect of topical 5-azacytidine in irritant and allergic contact dermatitis

نویسندگان

چکیده

DNA methylation is one of major epigenetic mechanisms by which regulate a panel gene expressions. An old but revisiting compound, 5-azacytidine, pyrimidine nucleoside analog cytidine that can inhibit methyltransferase, induce cell differentiation, and has direct cytotoxicity on abnormal bone marrow hematopoietic cells. Thus, systemic administration 5-azacytidine been approved for the treatment myelodysplastic syndrome acute myeloid leukemia. However, effect topical skin inflammation largely unknown. To this end, we utilized croton oil (CrO)-induced irritant contact dermatitis (ICD) model 2,4-dinitrofluorobenzene (DNFB)-induced allergic (ACD) model. At day -1, vehicle or 1 mg solution was applied to each ear. 0, 1% CrO both ear, ear thickness measured over time. Interestingly, swelling response in 5-azacytidine-treated significantly increased prolonged compared with vehicle-treated In DNFB-induced ACD model, application abdomen before sensitization 0.5% DNFB did not alter following swelling. sharp contrast, DNFB-sensitized mice elicitation 0.2% decreased These data suggest differently influences ICD as well phase ACD. Topical must modify bunch protein it could be therapeutic option

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2022

ISSN: ['1523-1747', '0022-202X']

DOI: https://doi.org/10.1016/j.jid.2022.09.069