منابع مشابه
06-P025 Rspo2 in laryngeal patterning
Neural tube defects (NTDs), such as spina bifida and anencephaly, are severe birth defects which result from failure of closure of the neural tube (the precursor of the brain and the spinal cord). In humans, NTDs affect 1 per 1000 pregnancies, with multifactorial aetiology suggestive of a combination of one or more genetic factors with contribution from environmental risk factors. The curly tai...
متن کاملR-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis.
Herein, we demonstrate that Lrp6-mediated R-spondin 2 signaling through the canonical Wnt pathway is required for normal morphogenesis of the respiratory tract and limbs. We show that the footless insertional mutation creates a severe hypomorphic R-spondin 2 allele (Rspo2(Tg)). The predicted protein encoded by Rspo2(Tg) neither bound the cell surface nor activated the canonical Wnt signaling re...
متن کامل06-P013 Disrupted patterning of the hypothalamus results in Kallmann Syndrome like defects in the zebrafish
the foregut endoderm and the defective expansion of the midand hindgut at early somite stages. However, there remains unclear whether or not Sox17 is required for the subsequent development, maturation and maintenance of the endoderm derivatives such as livers and pancreas due to the early embryonic lethal of Sox17-null mutant embryos before 10.0 dpc. Recently, we noticed the neonatal lethality...
متن کامل16-P025 The role of cilia during pectoral fin formation
hemizygous male mutants die by E12 and display neural tube defects, exencephaly and left–right asymmetry. Analysis of heterozygous female mutants revealed a severe brain phenotype including expansion of the ventral telencephalon in the dorsal part of the brain, reduction of the cortex and defects in the formation of dorsomedial telencephalic structures from E12.5. Morphological staining of muta...
متن کامل19-P025 Bone dynamics during adult zebrafish caudal fin regeneration
Planaria possess a population of pluripotent adult stem cells called neoblasts, capable of differentiating into all cell types required to regenerate entire animals from almost any fragment. The regeneration of different fragments is catalogued in a body of classical experiments by many eminent scientists. Here, we endeavour to explore these classical observations and insights and combine them ...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.251