054 EXTRACELLULAR SULFATASES SUPPORT CARTILAGE HOMEOSTASIS BY REGULATING BMP AND FGF SIGNALING PATHWAYS
نویسندگان
چکیده
منابع مشابه
Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.
The balance between anabolic and catabolic signaling pathways is critical in maintaining cartilage homeostasis and its disturbance contributes to joint diseases such as osteoarthritis (OA). A unique mechanism that modulates the activity of cell signaling pathways is controlled by extracellular heparan endosulfatases Sulf-1 and Sulf-2 (Sulfs) that are overexpressed in OA cartilage. This study ad...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2009
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(09)60077-7