0472 INSOMNIAS IN OSA PATIENTS WITH DIFERENT DEGREES OF SEVERITY: A STEP TOWARDS PHENOTYPING COMISA

Abstract Introduction With this pilot study, authors aimed to find how OSA and insomnias (sleep onset maintenance insomnia) interact. Methods Data from PSG-level 1 consecutive Obstructive Sleep Apnea (OSA) patients were retrospectively collected. Insomnia severity assessed. Arousals (A), arousal index (AI), wakefulness after sleep (WASO), total time (TST) eficiency (SE) used better characterize insomnias. Epworth Sleepiness Sclae (ESS) was assess excessive daytime sleepiness (EDS). Results From 87 patients, 43 (51.8 %): 53.5 % being females (F), where insomniacs (COMISA). Patients with COMISA distributed as follows: Mild (5 F: 22%; BMI=26.9±4.0 Kg/m2; Age=50.3±15.8 years old - yo; AHI=15.9±13.3 ev/h; ODI3%=4.0±3.9 SaO2mean=96.4±0.98 %; SaO2min=89.5±4.2 %) a TST of 414.5±70.9 min, SE=79.6±13.6 %, WASO=83.7±57.0 min 182.7±84.8 arousals (AI=26.6±11.1 ev/h); Moderate (8 35%; BMI=28.7±4.7 Age=53.5±13.4 AHI=24.4±3.1 ODI3%=8.8±5.7 SAO2mean=95.3±1.2 SaO2min=87.7±3.9 TTS=385.8±69.2 SE=80.7±12.6 WASO=81.4±62.3 178.8±69.5 (AI=27.5±8.9 Severe (10 BMI=30±5.2 Age=58.6±7.8 AHI=48.1± 19.9 ODI3%=25.4±25.1 SaO2mean=94.5±2.4%; SaO2min=82.6±10%) had TTS=386.5±64.5 SE=77.4±11.4%, WASO=93.3±49.8 274.2±95.3 (AI=42.6±12.9 ev/h). The others 40:48.2 presented Isolated OSA: (7 39 BMI=27.8±3.9 Age=48.3±12.1 AHI=8.9±3.2 ODI3%=2.5±2.7 SaO2mean=96.4±0.8%; SaO2min=90.8±2.6%) 423.9±36.7 SE=86.4±7.3%, WASO=58.1±27.2 151.6±42.1 (AI=21.6±6.5 39%; BMI=27.1±5.4 Age=53±13.1 AHI=21.2±3.8 ODI3%=6.9±3.8 SAO2mean=95.9±0.6%; SaO2min=86.7±4.1%) TTS=406.3±86.5 SE=79.4±15.2%, WASO=77.2.3±68 196.3.8±60.4 (AI= 29.1±6.6 (4 BMI=28.3±4.2 Age=62±12.5 AHI=51.8± 18.7 ODI3%=28.5±21.2 SaO2mean=93.9±3.5%; SaO2min=81.4±10.2%) TTS=385.9±105.7 SE=76.2±20.1%, WASO=92.9±80.1 272.7±115.6 (AI=42.5±14.9 ESS 10.1±7.9, 9±5.4 8±5.7 for the Mild, in group, 14.6±7.3, 10.9±5.2 5.9±5.2, mild, moderate severe forms isolated group. Conclusion complaints PSG correlates seems indicate clinically relevant phenotypes that would help manage condition at different degrees severity. Support (if any)