0465 Difficulty initiating and maintaining sleep is associated with increased blood pressure in people with obstructive sleep apnea

Abstract Introduction Approximately 30-50% of people with obstructive sleep apnea (OSA) have difficulty initiating and/or maintaining (DIMS). The co-occurrence OSA and DIMS is associated worse mental health quality life compared to alone. This study investigated potential associations between regular disturbances (defined over multiple months) blood pressure hypertension. Methods A validated under-mattress analyzer (WITHINGS) monitored in 12,287 participants ~6-months at home. mean apnea-hypopnea index (AHI), onset latency (SOL) wake after (WASO) were calculated the recording period. was defined as an average AHI ≥ 15 events/hour. SOL ≥30 min WASO 45min. Participants categorized into those neither condition (control), OSA-alone, DIMS-alone, OSA+DIMS. Blood measurements recorded using a home monitor define hypertension based on systolic ≥140 mmHg diastolic ≥90 mmHg. Associations OSA+DIMS regression analyses controlled for age, sex, BMI. Results middle-aged (Mean±SD; 50±12 y), mostly men (88%) overweight (BMI; 28±6 kg∙m-2). prevalence OSA-alone 10%, 21% 8%, respectively. (mean [95%CI]) 4.5 [4.1, 5.0] 2.6 [2.3, 2.93] higher values control. 5.9 [5.3, 6.6] 3.7 [3.3, 4.2] difference control, increased greater than (systolic: +1.4 [0.8, 2.0]; diastolic: +1.12 [0.7, 1.6] mmHg; p-values < 0.001).Furthermore , 37 [22 54] 60 [36 88] % increase had (17% [-1 38%]) OSA-alone. Conclusion when combined difficulties sleep, consistent insomnia symptomology, Support (if any)