0194: Flecainide and ajmaline challenge in Brugada syndrome patients under the age of 15 years
نویسندگان
چکیده
منابع مشابه
Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome.
OBJECTIVES The purpose of this study was to compare the effect of intravenous flecainide and ajmaline with respect to their ability to induce or accentuate the typical ECG pattern of Brugada syndrome. BACKGROUND Brugada syndrome is associated with a high incidence of sudden cardiac death. The typical ECG pattern of ST-segment elevation in the right precordial leads often is concealed, but it ...
متن کاملThe ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol.
AIMS The diagnostic ECG pattern in Brugada syndrome (BS) can transiently normalize and may be unmasked by sodium channel blockers such as ajmaline. Proarrhythmic effects of the drug have been well documented in the literature. A detailed protocol for the ajmaline challenge in Brugada syndrome has not yet been described. Therefore, we prospectively studied the risks of a standardized ajmaline te...
متن کاملThe challenges of performing ajmaline challenge in children with suspected Brugada syndrome
Correspondence to Dr Giulio Conte; [email protected] Brugada syndrome (BS) is an inheritable syndrome characterised by coved-type ST segment elevation in the right precordial leads (V1–V3) and increased risk of sudden death in the absence of structural heart disease. Intravenous administration of class IC antiarrhythmic drugs is an established tool to unmask the diagnostic Brugada EC...
متن کاملThe elusive link between LQT3 and Brugada syndrome: the role of flecainide challenge.
BACKGROUND Defects of the SCN5A gene encoding the cardiac sodium channel are associated with both the LQT3 subtype of long-QT syndrome and Brugada syndrome (BS). The typical manifestations of long-QT syndrome (QT interval prolongation) and BS (ST segment elevation in leads V1 through V3) may coexist in the same patients, which raises questions about the actual differences between LQT3 and BS. I...
متن کاملProarrhythmogenic effects of lamotrigine during ajmaline testing for Brugada syndrome
Introduction Sodium channel blockade (SCB) with a class Ia or Ic antiarrhythmic agent (eg, ajmaline or procainamide, respectively) is used in the unmasking and diagnosis of Brugada syndrome (BrS). SCB is performed frequently as part of family screening or in symptomatic patients with a suggestive electrocardiogram (ECG), and concurrent medications known to potentiate arrhythmias or contraindica...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2014
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(14)71358-8