003 Memory B cells of atopic individuals preferentially express IL-31RA: a putative role of IL-31 in B cell biology

The novel cytokine IL-31 and its receptor have been shown to play a central role in bridging the immune system with neurons, epithelial surfaces connective tissues. Although increasing evidence has demonstrated their inflammation, involvement expansion of distinct leukocyte subsets is not fully understood. Detailed analyses Il31-transgenic (Eμ-Lck) mice indicated that next induction pruritus skin lesions, also presented enlarged lymph nodes increased B cell frequency. Therefore, we aimed at characterizing signaling biology. Using flow cytometry, frequency total cells specific was assessed peripheral bone marrow wild-type controls. Moreover, IL-31RA expression analyzed on human from blood healthy atopic dermatitis donors. We observed significantly CD19+ mice. showed higher plasmablasts nodes. In human, memory represented major population expressing within compartment. Furthermore, patients elevated IgE levels (>1000 kU/l) compared This particular interest since DOCK8 loss-of-function mutations lead an upstream regulation pathway expression. deficiency-related hyper-IgE syndrome presents as combined immunodeficiency serum severe Taken together, these findings point biology IgE-producing phenotype.