β-Thalassemia Intermedia: A Bird’s-Eye View
نویسندگان
چکیده
منابع مشابه
β-Thalassemia Intermedia: A Bird’s-Eye View
Beta-thalassemia is due to a defect in the synthesis of the beta-globin chains, leading to alpha/beta imbalance, ineffective erythropoiesis, and chronic anemia. The spectrum of thalassemias is wide, with one end comprising thalassemia minor, which consists of a mild hypochromic microcytic anemia with no obvious clinical manifestations, while on the other end is thalassemia major, characterized ...
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To investigate the molecular basis of β -thalassemia intermedia in Northern Iraq and evaluate its management practices, a total of 74 patients from 51 families were enrolled. The patients were clinically and hematologically reevaluated, and had their β-thalassemia mutations characterized, as well as the number of α-globin genes and Xmn I (G)γ-158 (C>T) polymorphism studied. Out of 14 β-thalasse...
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Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum level...
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Thalassemia intermedia is a clinical definition applied to patients whose clinical phenotype is milder than that of thalassemia major. Criteria used to define thalassemia intermedia including age at presentation, hemoglobin or fetal hemoglobin levels and transfusion independence, are unsatisfactory. The possibility of typing the molecular defect allows a retrospective analysis of patients and o...
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O of Jan Drake’s happy innovations as editor of other significant events (i.e., the first issue of Genetics in 1916). These have fulfilled the retrospective function. Genetics was to initiate the publication of an essay, entitled Perspectives, at the beginning of each issue. The perspective and prospective functions have been achieved by articles that have integrated classic studies His idea wa...
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ژورنال
عنوان ژورنال: Turkish Journal of Hematology
سال: 2014
ISSN: 1300-7777
DOI: 10.4274/tjh.2014.0032