α-Methylacyl-CoA Racemase Spliced Variants and Their Expression in Normal and Malignant Prostate Tissues
نویسندگان
چکیده
منابع مشابه
Alpha-methylacyl-CoA-racemase expression in variants and unusual patterns of prostate carcinoma
Introduction: Alpha-methylacyl-CoA-racemase (AMACR) is a tumor marker expressed in prostate cancer. Literature data concerning its expression in different variants and unusual patterns of prostate carcinoma are uneven and less numerous. The present study investigates the AMACR expression in some rare forms of prostate carcinoma. Material and methods: Distinct variants and unusual patterns of pr...
متن کاملDiagnostic Value of Cytokeratin 34 beta E12 (Ck34βE12) and α-Methylacyl-CoA racemase (AMACR) Immunohistochemical Expression in Prostatic Lesions
Background & Objective: Some prostatic lesions contain small suspicious foci for prostatic carcinoma in which the morphological features are equivocal. Two immunohistochemical markers namely, cytokeratin 34 beta E12 (Ck34βE12) and α-Methylacyl-CoA racemase (AMACR), were evaluated in these lesions for a definitive diagnosis and avoiding misdiagnosis or overdiagnosis of prostatic...
متن کاملHumoral Immune Response to -Methylacyl-CoA Racemase and Prostate Cancer
Background: Although prostate-specific antigen (PSA) is a prototypic biomarker for prostate cancer, it has poor specificity. Expression of -methylacyl-CoA racemase (AMACR), which is involved in the conversion of Rstereoisomers of branched-chain fatty acids to S-stereoisomers, has been shown to be specifically increased in prostate cancer epithelia. However, attempts to detect AMACR in circulati...
متن کاملDiagnostic utility of α-methylacyl CoA racemase (P504S) & HMWCK in morphologically difficult prostate cancer
BACKGROUND To evaluate the diagnostic utility of alpha-methylacyl CoA racemase (P504S) & HMWCK (34beta E12) in morphologically difficult prostate cancer. METHODS A total of 1034 cases were reviewed and divided into benign (585) malignant (399) and suspicious (50). Immunohistochemistry with HMWCK and AMACR was done on the 50 suspicious cases along with controls. RESULTS Forty nine suspicious...
متن کاملExpression and Characterization of α-Methylacyl CoA Racemase from Anisakis simplex Larvae
Larval excretory-secretory products of Anisakis simplex are known to cause allergic reactions in humans. A cDNA library of A. simplex 3rd-stage larvae (L3) was immunoscreened with polyclonal rabbit serum raised against A. simplex L3 excretory-secretory products to identify an antigen that elicits the immune response. One cDNA clone, designated as α-methylacyl CoA racemase (Amacr) contained a 1,...
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ژورنال
عنوان ژورنال: Urology
سال: 2011
ISSN: 0090-4295
DOI: 10.1016/j.urology.2010.08.005