α-lipoic acid reduces liver injury in rats with acute pancreatitis

Consequences of the Combined α-tocopherol, Ascorbic Acid and α-lipoic Acid on the Glutathione, Cholesterol and Fatty Acid Composition in Muscle and Liver of Diabetic Rats

α-lipoic acid reduces hypertension and increases baroreflex sensitivity in renovascular hypertensive rats.

Renovascular hypertension has robust effects on control of blood pressure, including an impairment in baroreflex mechanisms, which involves oxidative stress. Although α-lipoic acid (LA) has been described as a potent antioxidant, its effect on renovascular hypertension and baroreflex sensitivity (BRS) has not been investigated. In the present study we analyzed the effects caused by chronic...

Α-lipoic Acid Reduces Neurogenic Hypertension by Blunting

22 We previously reported that ACE2 compensatory activity is impaired by the 23 disintegrin and metalloprotease 17 (ADAM17) and lack of ACE2 is associated 24 with oxidative stress in neurogenic hypertension. To investigate the relationship 25 between ADAM17 and oxidative stress, Neuro2A cells were treated with Ang-II 26 (100 nM) 24 h after vehicle or α-lipoic acid (LA: 500 μM). ADAM17 expressio...

Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats.

BACKGROUND The present study aimed to determine the effects of alpha lipoic acid (ALA) on blood and tissue biochemical parameters, as well as tissue histopathology, in an experimental rat model of cerulein-induced acute pancreatitis (AP). METHODS Three groups consisting of eight rats each were used, as follows: Group 1, controls; Group 2, cerulein-induced pancreatitis group treated with salin...

Alpha-lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats.

AIM Alpha-lipoic acid (ALA) has been used as an antioxidant. The aim of this study was to investigate the effect of alpha-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats. METHODS ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 microg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5...