β-Cyclodextrin catalyzed synthesis of substituted indoles in aqueous medium

A Facile β-Cyclodextrin-Catalyzed synthesis of substituted benzofuran from salicyaldehyde and alpha tosyl ketone

Benzofuranones have attracted considerable attention with regard to their pharmaceutical activity and the various approaches directed towards their synthesis .The simple benzofuran derivatives like 2-nitrobenzofuran, 2-acetyl benzofurans are well known as bio-dynamic agents possessing various pharmacological properties.spasmolytic activity on the intestine of the guinea pig and dilatory effects...

Rhodium-Catalyzed Synthesis of 2,3-Disubstituted Indoles from β,β-Disubstituted Stryryl Azides**

Efficient palladium-catalyzed synthesis of substituted indoles employing a new (silanyloxyphenyl)phosphine ligand.

The new and easily prepared OTips-DalPhos ligand (L1) offers broad substrate scope at relatively low loadings in the palladium-catalyzed C-N cross-coupling/cyclization of o-alkynylhalo(hetero)arenes with primary amines, affording indoles and related heterocyclic derivatives in high yield.

Palladium on carbon-catalyzed synthesis of 2- and 2,3-substituted indoles under heterogeneous conditions.

A mild, efficient and LiCl-free synthetic method for indole derivatives based on the heteroannulation of alkynes with 2-iodoanilines was achieved using palladium on carbon (Pd/C) and NaOAc in heated NMP. The N-tosyl protection of 2-iodoaniline expedited the reaction progress, while other protecting groups, such as tert-butoxycarbonyl, acetyl, and benzyloxycarbonyl groups, underwent deprotection...

Synthesis of amino-substituted indoles using the Bartoli reaction.

We report herein the concise preparation of a range of functionalised aminoindoles via a new application of the Bartoli reaction. Scope and limitations of the methodology have been extensively studied to reveal the importance of protecting groups and substitution patterns. The use of amino substituted nitroanilines for the Bartoli reaction is to our knowledge unprecedented. Our work thus repres...