β-Catenin Signaling: Therapeutic Strategies in Oncology
نویسندگان
چکیده
منابع مشابه
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contribut...
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will break the barrier, making the TJ a frequent contributor to a vast range of pathologies of blood vessels and epithelial organs. Since most of these insults have pleotropic cellular effects, it is difficult to envision therapies that could target specific TJ components or functions. In contrast, some assaults on the barrier are quite specific. For example, house dust mites excrete a fecal pr...
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Objective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and su...
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Molecules labeled in green and blue play positive and negative roles in Wnt/β-catenin signaling, respectively. Molecules that are labeled in both colors have dual roles. (Top left) Wnt biogenesis. A lipid modification is added to Wnt ligands by Porc in the endoplasmic reticulum (ER). Wnt ligands are glycosylated in the ER and Golgi and require Wls (also known as Evi) to traffic through the Golg...
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Wnt growth factors signal through either the canonical Wnt (Wg)-Frizzled (Fz)/β-catenin-dependent pathway or through non-canonical Wnt pathways, such as the Wnt/Fz-planar cellular polarity (PCP) pathway. These 2 pathways are evolutionarily highly conserved from invertebrates to humans. Canonical Wnt/ β-catenin signaling is essential for many aspects of development. In vertebrates, it controls t...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2002
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.309