β-Carboline Alkaloids from Galianthe ramosa Inhibit Malate Synthase from Paracoccidioides spp.
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چکیده
منابع مشابه
Three novel β-carboline alkaloids from Gelsemium elegans.
Three novel β-carboline alkaloids characterized with a unique degraded monoterpenoid moiety, gelebolines A-C (1-3), together with 11 known alkaloids of different types, were isolated from the roots of Gelsemium elegans. The structures of new alkaloids were established on the basis of analysis of spectroscopic data. It is the first example for report of β-carboline from genus Gelsemium (Loganiac...
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Paracoccidioides is the agent of paracoccidioidomycosis. Malate synthase plays a crucial role in the pathogenicity and virulence of various fungi, such as those that are human pathogens. Thus, an inhibitor of this enzyme may be used as a powerful antifungal without side effects in patients once these enzymes are absent in humans. Here, we searched for compounds with inhibitory capacity against ...
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From Ribes nigrum L. two ß-carboline alkaloids (deshydroxymethyl flazin (1) and flazin methyl ether (2)) could be isolated in minute amounts. The structure elucidation is described. The two compounds are present in the freshly pressed juice, but they are also formed during storage of the juice by condensation of tryptophane with ascorbic acid or its degradation products. This could be shown by ...
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Two alkaloids, canthin-6-one 9-O-beta-glucopyranoside and 7-hydroxy-beta-carboline 1-propionic acid, were isolated from the roots of Eurcoma harmandiana together with the five known canthin-6-one alkaloids, 9-hydroxycanthin-6-one, 9-methoxycanthin-6-one, 9,10-dimethoxycanthin-6-one, canthin-6-one and canthin-6-one N-oxide, and the two known beta-carboline alkaloids, beta-carboline 1-propionic a...
متن کاملProduction of β-carboline alkaloids on co-culture of peganum harmala L
Introduction: peganum harmala L. (Zygophyllaceae) and varthemia persica DC (Compositeae) were used for co-culture studies. P.harmala was found to be one of the richest natural sources of β-carboline alkaloids. β-carboline alkaloids posses different neuropharmacologic activities including BDZ antagonism, MAOinhibitor and aminoreuptake inhibitor. The production of β-carboline alkaloids in cell ...
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ژورنال
عنوان ژورنال: Planta Medica
سال: 2014
ISSN: 0032-0943,1439-0221
DOI: 10.1055/s-0034-1383305