BACKGROUND The benefit of retrograde cerebral perfusion (RCP) with profound hypothermic circulatory arrest has been subject to much debate. We examined our experience with ascending and transverse arch repairs to determine the impact of retrograde cerebral perfusion on stroke and mortality. METHODS AND RESULTS Between August 1991 and June 2007, we performed 1107 repairs of the ascending and t...

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding the 3¢ untranslated regions of target mRNAs. We examined the subcellular distribution of three miRNAs in exponentially growing HeLa cells and found that the vast majority are associated with mRNAs in polysomes. Several lines of evidence indicate that most of these mRNAs, including a known miRNA-regulated target (KRAS ...

The Thriposha programme is a community-level nutrition intervention in Sri Lanka that provides a combination of energy, protein and micronutrients as a 'ready-to-eat' cereal-based food. We measured the bioavailability of Fe and Zn from Thriposha formula at two different molar ratios of Zn:Fe in order to determine the effect on Fe and Zn absorption. Children 4-7 years (n 53) were given a meal pr...

Background. The sparse reporting of abdominal compartment syndrome (ACS) in the pediatric literature may reflect inadequate awareness and recognition among pediatric healthcare providers (HCP). Purpose. To assess awareness of ACS, knowledge of the definition and intraabdominal pressure (IAP) measurement techniques used among pediatric HCP. Method. A written survey distributed at two pediatric c...

Stem cell persistence into adulthood requires self-renewal from early developmental stages. In the developing mouse brain, only apical progenitors located at the ventricle are self-renewing, whereas basal progenitors gradually deplete. However, nothing is known about the mechanisms regulating the fundamental difference between these progenitors. Here we show that the conditional deletion of the...

The protoberberine alkaloid berberine carries methylenedioxy moiety and exerts a variety of pharmacological effects, such as antiinflammation and lipid-lowering effects. Berberine causes potent CYP1B1 inhibition, whereas CYP1A2 shows resistance to the inhibition. To reveal the influence of oxidative metabolism on CYP1 inhibition by berberine, berberine oxidation and the metabolitemediated inhib...

Schizophrenia is a chronic, complex and heterogeneous mental disorder, with pathological features of disrupted neuronal excitability and plasticity within limbic structures of the brain. These pathological features manifest behaviorally as positive symptoms (including hallucinations, delusions and thought disorder), negative symptoms (such as social withdrawal, apathy and emotional blunting) an...

the higher levels of essential elements in soil may be caused in optimum yields and crop quality. so it seems to be necessary to examine different levels of nutrients like fe and zn on plants and their productivity. to evaluate effects of iron and zinc application on yield and yield components of pimpinella anisum an experiment was conducted at the research farm of urmia university in 2009. tre...

this study was carried out to determination of in vitro binding capacity of organic (wheat and barley) and inorganic (perlite) sources for mn, zn, cu, and fe. for this reason wheat and barley were analyzed chemically for moisture, protein, ash, and ether extract, total carbohydrate, ndf, adf, adl, crude fiber, viscosity, cellulose, and total dietary fiber. the in vitro mineral binding capacity ...

Historic lead and zinc (Pb-Zn) mining in southeast Missouri’s ―Old Lead Belt‖ has left large chat piles dominating the landscape where prior to 1972 mining was the major industry of the region. As a result of variable beneficiation methods over the history of mining activity, these piles remain with large quantities of unrecovered Pb and Zn and to a lesser extent cadmium (Cd). Quantifying the r...