A significant portion of the evolution of Linked Data datasets lies in updating the links to other datasets. An important challenge when aiming to update these links automatically under the open-world assumption is the fact that usually only positive examples for the links exist. We address this challenge by presenting and evaluating WOMBAT, a novel approach for the discovery of links between k...

The koala has evolved to become a specialist Eucalyptus herbivore since diverging from its closest relative, the wombat, a generalist herbivore. This niche adaptation involves, in part, changes in the gut microbiota. The goal of this study was to compare koala and wombat fecal microbiomes using metagenomics to identify potential differences attributable to dietary specialization. Several popula...

Southern hairy-nosed wombats (Lasiorhinus latifrons) are fossorial marsupials that live in large burrow systems where their digging behaviour brings them into conflict with agriculture. In the absence of any available control options, non-selective culling is the primary mode of wombat management. This approach is contentious and has unknown implications for long-term wombat conservation. Preda...

The major bile acids present in the gallbladder bile of the common Australian wombat (Vombatus ursinus) were isolated by preparative HPLC and identified by NMR as the taurine N-acylamidates of chenodeoxycholic acid (CDCA) and 15alpha-hydroxylithocholic acid (3alpha,15alpha-dihydroxy-5beta-cholan-24-oic acid). Taurine-conjugated CDCA constituted 78% of biliary bile acids, and (taurine-conjugated...

We examined "descriptor collision" for several chemical fingerprint systems (MDL 320, Daylight, SMDL), and for a 2D-based descriptor set. For large databases (ChemNavigator and WOMBAT), the smallest collision rate remains around 5%. We systematically increase the "descriptor collision" rate (here termed "descriptor confusion"), in order to design a set of "descriptors to mask chemical structure...

Abstract Establishing relationships between soft tissues and bones in living species can inform our understanding of functional adaptations their extinct kin the absence direct data on habitual behaviours. The koala wombats are only surviving vombatiform suborder, represent extant phylogenetic bracket for dozens fossil marsupial across nine families. Here we present first quantitative architect...

The WOMBAT project is a collaborative European funded research project that aims at providing new means to understand the existing and emerging threats that are targeting the Internet economy and the net citizens. The approach carried out by the partners include a data collection effort as well as some sophisticated analysis techniques. In this chapter, we present one of the threats-related dat...

Trypanosome infections in their natural hosts are frequently difficult to detect by microscopy, and culture methods are unreliable and not suitable for all species of Trypanosoma. A nested PCR strategy for detecting and identifying Trypanosoma species, suitable for detecting both known and unknown trypanosomes, is presented. Thirty-two blood samples from 23 species of Australian birds and mamma...

A comparison of the erythrocyte (RBC) antioxidant metabolites and enzymes in nine marsupial and two monotreme species was carried out. Reduced glutathione (GSH) concentrations were comparable with those reported for other marsupial and eutherian species. An important finding was that the erythrocytes of the southern hairy nosed wombat regenerated GSH faster than the erythrocytes from its close ...

Trypanosoma irwini was previously described from koalas and we now report the finding of a second novel species, T. gilletti, as well as the extension of the host range of Trypanosoma copemani to include koalas. Phylogenetic analysis at the 18S rDNA and gGAPDH loci demonstrated that T. gilletti was genetically distinct with a genetic distance (± s.e.) at the 18S rDNA locus of 2.7 ± 0.5% from T....