BACKGROUND Growth hormone secretion and muscle mass decline from midpuberty throughout life, culminating in sarcopenia, frailty, decreased function, and loss of independence. The decline of growth hormone in the development of sarcopenia is one of many factors, and its etiologic role needs to be demonstrated. OBJECTIVE To determine whether MK-677, an oral ghrelin mimetic, increases growth hor...

New product development, based on SOC (System on a Chip) and IP (Intellectual Property) cores, requires, as much as possible, design and test [1]. High design productivity drives the need for test preparation to be carried out as early as possible in the design flow, thus at RTL (Register Transfer Level) [2]. However, RT-level test patterns are not routinely reused for production test, since hi...

A randomized complete block design experiment was conducted using 408 crossbred pigs to evaluate the effects of six dietary Ca/P levels for growing swine (18 to 57 kg). Total dietary P levels ranged from .40 to .90% in .1% intervals with Ca concurrently increased at a 1.3:1 ratio in a 16% protein corn-soybean meal diet. Dicalcium phosphate and limestone were the source of inorganic Ca and P. Fo...

Obesity and menopausal estrogen therapy are established risk factors for endometrial cancer. However, the joint effects of obesity and menopausal hormone therapy on endometrial cancer risk are incompletely understood. We addressed this issue in a cohort of 103,882 women ages 50 to 71 years at baseline in 1995 to 1996. During a median of 4.6 years, which contributed to a total of 455,304 person-...

One hundred twenty 4-mo-old wether lambs born to Targhee ewes and sired by six rams each from Merino (Finewool, FM and Strongwool, SM), Rambouillet (Dubois, DR and Texas, TR), and Targhee (T) breeds were randomly assigned to predetermined slaughter weight groups of 43, 48, 52, and 57 kg and evaluated for growth and carcass traits. Overall mean ADG and feed conversion rate (FC, kilograms of feed...

A study involving 244 pigs initially averaging 13 kg was conducted at two stations to evaluate tiamulin as a growth promotant for growing swine. In each experiment, four replicate pens of five (Exp. 1) or six (Exp. 2) pigs/pen were used to evaluate each treatment. In Exp. 1, pigs were fed 0, 11, 22 or 44 ppm tiamulin from 15 to 58 kg, then fed a nonmedicated control diet for the remainder of th...

OBJECTIVE The 677 C>T and 1298 A>C polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene have been widely reported and considered to have a significant effect on breast cancer risk, but the results are inconsistent. A meta-analysis based on 57 eligible studies was carried out to clarify the role of MTHFR gene polymorphisms in breast cancer. METHODS AND RESULTS Eligible articles we...

Fruit productivity and quality of eight years peach and nectarine cultivars (Rich Lady, Ryan Sun, Ruby Diamond and Venus) grafted onto Cadaman-Avimag, Viking, Atlas, GxN 15, GF 677, MRS 2/5 and Nemaguard (control) rootstocks were evaluated. A Split Plot experimental design was used, with each rootstock/scion combination as an experimental unit. Total yield, fruit size distribution, number of fr...