UNLABELLED Wegeners Granulomatosis is a condition associated with systemic vasculitis which can present with upper respiratory tract symptoms initially. On September 2001, a 15-year-old girl presented with symptoms of nasal block for 3 weeks. She later developed joint pains and worsening renal status requiring dialysis. A renal biopsy was performed which showed pauci-immune cresentric glomerulo...

Wegeners granulomatosis is a necrotizing granulomatous vasculitis with multisystemic involvement. We present two cases of Wegener's presenting with otological manifestations as the first symptom. These symptoms are subtle and diagnosis may be easily overlooked. Hence a high index of suspicion is required. Early diagnosis and treatment goes a long way in improving the outcomes and in preventing ...

Vasculitis (Wegeners Granulomatosis and Microscopic Polyangiitis) and Tuberculosis share many features including constitutional symptoms and respiratory tract involvement. The presence of kidney involvement with new onset azotaemia and active urine sediment support the diagnosis of vasculitis. We describe two cases that were diagnosed to be suffering from tuberculosis and placed on anti-tubercu...

Background: The presence of anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener’s granulomatosis (WG), implicate the neutrophil as a key effector cell. Previous studies have reported elevated neutrophil counts in the lung although the determinants of neutrophil chemotaxis in the WG lung are unknown. Methods: BALF cell counts, myeloperoxidase (MPO) and chemokines were measured in 27 patient...

The clinical course, radiographic features and pathology of 18 cases of Wegeners granulomatosis with pulmonary involvement are presented. Glomerulitis and generalized vasculitis were not features of this series. Nodular pulmonary densities characterized the chest radiographs. Five cases showed improvement in one lung with progression in another, thus dif­ ferentiating the disease from neoplasia...

OBJECTIVE Wegener granulomatosis (WG) presents nasal, laryngeal and otologic symptoms as an initial signs of the disease and finally can affect the ENT region in 3/4 patients. The authors want to analyze 7 cases of WG with early aural symptoms, connected with the diagnostics dilemma, discuss the problems of otologic manifestation in WG and present the newest concepts of diagnostics and treatmen...

Pulmonary-renal syndrome (PRS) is defined as a diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. We present a retrospective study of 22 consecutive patients with Wegener’s granulomatosis (WG). Logistic regression analysis and a Wilcoxon test were included in the statistics. Survival time death risk were assessed using the Kaplan-Meier estimator and the Cox proportional haz...

The causes of multiple pulmonary nodules in a pediatric patient include infections, malignancies, sarcoidosis, granulomatosis with polyangiitis (GPA; formerly Wegener’s granulomatosis), eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg Strauss), hypersensitivity pneumonitis, and lymphomatoid granulomatosis. The clinician is faced with the challenging task of combining clinical...