We asked if the higher work of breathing (Wb) during exercise in women compared with men is explained by biological sex. We created a statistical model that accounts for both the viscoelastic and the resistive components of the total Wb and independently compares the effects of biological sex. We applied the model to esophageal pressure-derived Wb values obtained during an incremental cycle tes...

Although considerable attention has been directed in the field of gene therapy toward elucidating the mechanism by which a transduced cell could kill a bystander cell, little is known about how bystander cells may affect transduced cells. We hypothesized that bystander cells, particularly if they were capable of gap junctional communication, could protect cells transduced with the herpes simple...

The epidermal growth factor receptor (EGFR) is a therapeutic target (oncotarget) in NSCLC. Using in vitro EGFR kinase activity system, we identified a novel small molecule, WB-308, as an inhibitor of EGFR. WB-308 decreased NSCLC cell proliferation and colony formation, by causing G2/M arrest and apoptosis. Furthermore, WB-308 inhibited the engraft tumor growths in two animal models in vivo (lun...

OBJECTIVES To examine the prevalence of and factors associated with potentially unnecessary repeat confirmatory testing after initial HIV diagnosis and the relationship of repeat testing to medical care engagement. DESIGN South Carolina HIV/AIDS surveillance data for 12,504 individuals who were newly diagnosed with HIV infection between January 1997 and December 2008 were used for this analys...

BACKGROUND AND PURPOSE Alzheimer disease (AD) is accompanied by macroscopic atrophy on volumetric MR imaging. A few studies have also demonstrated reduction in magnetization transfer ratio (MTR), suggesting microstructural changes in remaining brain tissue. This study assessed the value of measuring MTR in addition to volumetric MR in differentiating patients with AD from control subjects. MA...

Methods One-hundred-sixty-six patients suspected for ovarian carcinoma underwent 3T WB-DWI/MRI using 2 b-values (b=0-1000 s/mm), T2-weighted and contrast-enhanced T1-weighted sequences in addition to contrast-enhanced CT. WB-DWI/MRI and CT were independently and blindly evaluated and correlated with pathological findings at surgery as reference standard. Superiority was assessed using two-taile...

Accurate estimation of terrestrial water storage anomalies (TWSA) is crucial for the sustainable management resources and human living. In this study, long-term TWSA estimates are reconstructed by integration multiple meteorological products balance (WB) method at 0.5° × resolution, generating a total 12 combinations different data. This scheme applied to 10 river basins (RBs) within China vali...

Whole-body (WB) dynamic PET has recently demonstrated its potential in translating the quantitative benefits of parametric imaging to the clinic. Post-reconstruction standard Patlak (sPatlak) WB graphical analysis utilizes multi-bed multi-pass PET acquisition to produce quantitative WB images of the tracer influx rate K i as a complimentary metric to the semi-quantitative standardized uptake va...

With rapid advancements in exoskeleton technologies, a whole-body powered (WB-PEXO) for augmenting human physical capacity (a “super-operator”) is generating increasing attention as an integral part of Industry 4.0. Our understanding WB-PEXO use lagging, however, largely due to the lack detailed evaluations via human-subjects testing WB-PEXO. We examined (independently from manufacturer WB-PEXO...

The aims of the present study were, firstly, to determine the reliability and reproducibility of an agility T-test and Yo-Yo 10 m recovery test; and secondly, to analyse the physical characteristics measured by sprint, agility, strength and endurance field tests in wheelchair basketball (WB) players. 16 WB players (33.06 ± 7.36 years, 71.89 ± 21.71 kg and sitting body height 86.07 ± 6.82 cm) be...