نتایج جستجو برای: warfarin dose requirements

تعداد نتایج: 518675  

Journal: :international journal of hematology-oncology and stem cell research 0
behzad poopak dcls,phd in hematology, islamic azad university, tehran medical sciences branch, tehran, iran saghar rabieipoor msc in biotechnology, payvand clinical and specialty laboratory, tehran, iran nazila safari msc in molecular oncology, payvand clinical and specialty laboratory, tehran, iran emadedin naraghi msc in bioscience, payvand clinical and specialty laboratory, tehran, iran fatemeh sheikhsofla msc in cell and molecular biology, payvand clinical and specialty laboratory, tehran, iran gelareh khosravipoor md, payvand clinical and specialty laboratory, tehran, iran 4msc in bioscience, payvand clinical and specialty laboratory, tehran, iran

background: although catalytic properties of different genetic polymorphisms of vkorc1 and cyp2c9 products have been identified, there is limited study available regarding warfarin dose requirement in iranian patient population. this study investigates the impact of these polymorphisms on 115 patients, referred to payvand clinical and specialty laboratory for determining the appropriate dose of...

Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (...

آهنگر, نعمت الله , جان بابایی, قاسم , صالحی فر, ابراهیم, فرهادی, فهیمه,

Background and purpose: The objective of this study was to determine the influence of 3 vitamin K epoxide reductase complex subunit 1 (VKORC1) polymorphisms (-1639G>A, 1173C>T and 3730G>A) on warfarin dose requirement in patients from Mazandaran province, Iran. Materials and methods: A total of 29 patients taking warfarin for at least 3 months and had stable dose requirements were enrolled i...

Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (...

Background: Many cardiovascular diseases may require lifelong anticoagulation therapy. Warfarin is the most prescribed medication in this regard, however, it has serious side effects. Recently the new issue regarding to warfarin dosing is considered in which some single nucleotide polymorphisms (SNPs) affecting cytochrome P450 system can impact on warfarin metabolism and dosing. Methods: 230 c...

Background: Many cardiovascular diseases may require lifelong anticoagulation therapy. Warfarin is the most prescribed medication in this regard, however, it has serious side effects. Recently the new issue regarding to warfarin dosing is considered in which some single nucleotide polymorphisms (SNPs) affecting cytochrome P450 system can impact on warfarin metabolism and dosing. Methods: 230 c...

Journal: :British Journal of Clinical Pharmacology 2002

Journal: :Drug metabolism and pharmacokinetics 2009
Edwin Sandanaraj Suman Lal Yin Bun Cheung Xiaoqiang Xiang Ming Chai Kong Lai Heng Lee London Lucien Ooi Balram Chowbay

SUMMARY Warfarin-induced bleeding complications and high inter-patient variability are major hindrances to oral anticoagulant therapy. The present study identifies the influence of VKORC1 diplotypes, CYP2C9 and CYP2C19 variants on warfarin disposition and dose requirements in Chinese patients (n=107). The study subjects were genotyped for VKORC1, CYP2C9 and CYP2C19 polymorphic variants. Weekly ...

Journal: :Age and ageing 1996
H A Wynne F Kamali C Edwards A Long P Kelly

This longitudinal study was designed to establish the rate of age-related change in warfarin dose requirements. Warfarin dosage was recorded retrospectively in 104 patients who had been stabilized on warfarin for a median period of 10 years (range 6-24 years) for prophylaxis of thromboembolic disease. There was a significant negative correlation between dosage and age at the start of therapy (p...

2016
IS Hamadeh MH Shahin SM Lima F Oliveira L Wilson SI Khalifa TY Langaee RM Cooper‐DeHoff LH Cavallari JA Johnson

Genotype-based algorithms that include VKORC1 and CYP2C9 genotypes are less predictive of warfarin dose variability in Africans as opposed to Europeans. Polymorphisms in GGCX, FPGS, or STX1B are associated with warfarin dose requirements in African-Americans. We sought to determine if they influenced warfarin dose in European-Americans, and another African population, specifically Egyptians. We...

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