in this study, anion-exchange chromatography was used to purify factor vii and factor ix from prothrombin complex (ppsb), which contains coagulation factors ii, vii, ix and x. for this purpose, deae-sepharose cl-6b gel , pharmacia column xk-26 , high flow rate and two stepwise gradients with phosphate citrate buffer were used. the yield of the two lyophylized products, factor vii and factor ix ...

the risks of transmitting viral infection by blood and plasma-derived products have long been known and still remain an area of concern. in this study, in the process of purifying human factor vii from prothrombin complex, sid treatment using tri-n-butyl phosphate and tween 80 was employed and its capability and efficacy was studied. the results indicated that the process did not affect the bio...

human parvovirus b19, the causative agent of fifth disease in childhood, is non-enveloped dna virus and resistant to many physicochemical agents. b19 is a potential risk to hemophiliac patients receiving blood products. to determine the prevalence of the corresponding antibody in patients with hemophilia a or b or von will brand’s disease (vwbd), we tested 180 hemophilia patients aged 1-45 year...

Background and Aims: Fresh Frozen Plasma (FFP) is one of blood components. The risk of transmission of viruses from blood components regardless selection of blood donors and screening donated blood still remains. There are several methods for viral inactivation. In this study methylene blue (MB) photo inactivation process was used for inactivating viruses. Materials and Methods: In this study M...

An in vitro study was conducted to know the veridical properties of silver nanoparticles synthesized from   locally available white button mushrooms (Agaricus bisporus). The characterized colloidal silver nanoparticles exhibited as an excellent virucidal property on viral strain Bacteriophage. The viral inactivation process was increased with increasing the concentration of colloidal s...

An in vitro study was conducted to know the veridical properties of silver nanoparticles synthesized from   locally available white button mushrooms (Agaricus bisporus). The characterized colloidal silver nanoparticles exhibited as an excellent virucidal property on viral strain Bacteriophage. The viral inactivation process was increased with increasing the concentration of colloidal s...

Background and Aims: Despite the screening of blood donors, blood transfusion represents an ideal port of entry for blood-borne infection. Blood-borne pathogen transmission has been a concern since the earliest days of transfusion. The blood product of platelet (PLT) concentrates is still faced with the risk of bacterial and viral contaminations. Pathogen inactivation technologies offer a proac...

Background and Aims: Despite the screening of blood donors, blood transfusion represents an ideal port of entry for blood-borne infection. Blood-borne pathogen transmission has been a concern since the earliest days of transfusion. The blood product of platelet (PLT) concentrates is still faced with the risk of bacterial and viral contaminations. Pathogen inactivation technologies offer a proac...

background and aims: despite the screening of blood donors, blood transfusion represents an ideal port of entry for blood-borne infection. blood-borne pathogen transmission has been a concern since the earliest days of transfusion. the blood product of platelet (plt) concentrates is still faced with the risk of bacterial and viral contaminations. pathogen inactivation technologies offer a proac...