The main cardiovascular changes associated with aging included decreased heart rates, oxygen extraction, arterial stiffening, vasoconstriction, systolic blood pressure elevation, myocardial thickening, reduced diastolic filling rate, rhythmic rate changes, and action potential prolongation. Multifactorial risk can include the pathology of diseased. This study aims to ascertain relationship betw...

A hallmark of hypertension is an increase in arterial myocyte voltage-dependent Ca2+ (CaV1.2) currents that induces pathological vasoconstriction. CaV1.2 channels are heteromeric complexes composed of a pore-forming CaV1.2α1 with auxiliary α2δ and β subunits. Molecular mechanisms that elevate CaV1.2 currents during hypertension and the potential contribution of CaV1.2 auxiliary subunits are unc...

Matthews, H. R., Meade, J. B, and Evans, C. C. (1974). Thorax, 29, 343-348. Significance of prolonged peripheral vasoconstriction after open-heart surgery. Abnormally prolonged peripheral vasoconstriction has been detected prospectively by means of a toe temperature nomogram in 15 (11-5%) out of 131 patients following cardiopulmonary bypass. This state has been associated with a 53% incidence o...

BACKGROUND/AIMS Copper is an essential trace element for normal cellular function and contributes to critical physiological or pathological processes. The aim of the study was to investigate the effects of copper on vascular tone of rat mesenteric artery and compare the effects of copper on noradrenaline (NA) and high K(+) induced vasoconstriction. METHODS The rat mesenteric arteries were iso...

Respiratory Alkalosis due to changes in sympathetic hyperarousal during pathological emotional states can change our cognitive abilities. This occurs through the effects of Alkalosis upon cerebral vasoconstriction and the amount of ionized calcium in the serum. The effects on our cognition and "sense of self " could be considerable.

it has been shown in some investigations that cardiovascular events are the main causes of death in hemodialysis patients. the exact etiology is unknown but some of the articles have reported a relation between aluminium ions in the dialysis solution and cardiovascular disorders. to determine the probable effect of aluminium on vasculature function, in vitro effects of aluminium ion on vasocons...

OBJECTIVE The mechanisms regulating spiral modiolar artery (SMA) tone are not known, yet their characterization is pivotal for understanding inner ear blood flow regulation. Sphingosine-1-phosphate (S1P), known to stimulate vasoconstriction in several vascular beds, is a candidate regulator of SMA tone with potential pathophysiological relevance. METHODS Gerbil SMAs were isolated, cannulated ...

Vibration syndrome is generally considered to consist of disorders in the upper extremities which are directly exposed to vibration. However, it has been shown that vibration syndrome patients have circulatory disturbances in the foot as well: several chain-saw operators, who were little exposed to vibration of the foot, had Raynaud's phenomenon of the toes, and those with frequent attacks of v...