preeclampsia is an important pregnancy disorder with serious maternal and fetal complications which its etiology has not been completely understood yet. early diagnosis and management of disease could reduce its potential side effects. the vascular endothelial growth factor (vegf) family including vegf-a is the most potent endothelial growth factor which induces angiogenesis and endothelial cel...

the role of angiogenic molecules, like vascular endothelial growth factor (vegf) and fibroblast growth factor (fgf) in tumor angiogenesis was well confirmed. photodynamic therapy (pdt) action is, to very high degree, based on tumor vasculature damage. therefore, it seemed to be important to evaluate growth factor receptors after pdt. the extent of receptor expression was studied by immuno-histo...

The role of angiogenic molecules, like vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) in tumor angiogenesis was well confirmed. Photodynamic therapy (PDT) action is, to very high degree, based on tumor vasculature damage. Therefore, it seemed to be important to evaluate growth factor receptors after PDT. The extent of receptor expression was studied by immuno-histo...

Vascular endothelial growth factor receptor-2 (VEGFR-2); a cell surface receptor for vascular endothelial growth factors, is a key pharmacological target involved in the cell proliferation/angiogenesis. It has been revealed that VEGFR-2 induces proliferation through activation of the extracellular signal-regulated kinases pathway. In this regard, targeting the VEGFR-2 has been considered as an ...

Vascular endothelial growth factor receptor-2 (VEGFR-2); a cell surface receptor for vascular endothelial growth factors, is a key pharmacological target involved in the cell proliferation/angiogenesis. It has been revealed that VEGFR-2 induces proliferation through activation of the extracellular signal-regulated kinases pathway. In this regard, targeting the VEGFR-2 has been considered as an ...

vascular endothelial growth factor receptor-2 (vegfr-2); a cell surface receptor for vascular endothelial growth factors, is a key pharmacological target involved in the cell proliferation/angiogenesis. it has been revealed that vegfr-2 induces proliferation through activation of the extracellular signal-regulated kinases pathway. in this regard, targeting the vegfr-2 has been considered as an ...

background and objective: vascular endothelial growth factor (vegf) and its receptors (vegf-r1 and r2) are major regulators of angiogenesis. this study was designed to assess serum levels of vegf and vegf-r1 and their prognostic significance in newly diagnosed childhood acute leukemia. materials and methods: for this purpose, vegf and vegf-r1 were determined using enzyme linked immuno-sorbant a...

previous studies have demonstrated that vascular endothelial growth factor (vegf) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and inflammatory cells. we aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of vegf and the soluble form of its receptor-1 (svegfr1) to the severity of ...

Vascular and lymphatic malformations represent a challenge for clinicians. The identification of inherited somatic mutations in important signaling pathways, including the PI3K (phosphoinositide 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target rapamycin), RAS (rat sarcoma)/RAF (rapidly accelerated fibrosarcoma)/MEK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated ki...

Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosph...